milk thistle and cymbalta
2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Adv Ther. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Is there also a role for herbs and supplements? These side effects may be mild or severe. 2016;5147468. doi:10.1155/2016/5147468. Moderately clinically significant. Read our. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Effects of Silybum marianum (L.) Gaertn. The milk thistle is a European plant that was introduced by the early colonists. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Milk thistle could play an essential role in supporting bone health. An older study found that milk thistle extract had a positive effect on immune response in humans. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Some of the studies have been of poor quality, too. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Herbal remedies are usually the talk of the town. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Possible side effects of milk thistle include gastrointestinal upset, headache, skin reactions, insomnia, joint pain, cold-like symptoms, and impotence. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Other potential benefits include . Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. There are no guidelines regarding a standard dose of milk thistle. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). If you notice other effects not listed above, contact your doctor or pharmacist. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Dupuis ML, Conti F, Maselli A, et al. Am J Gastroenterol. Of the total drug interactions, Fried MW, Navarro VJ, Afdhal N, et al. An important part of taking supplements is proper storage. It is also unknown whether milk thistle is safe for children. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. We comply with the HONcode standard for trustworthy health information. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. This publication is not copyrighted and is in the public domain. It is unknown if this product passes into breast milk. Dosage: How Much Milk Thistle Should I Take? Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. No related drugs found for this medication. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Milk thistle. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. What Happens If I Take Too Much Milk Thistle? This mixture contains chemical compounds, some of which may have benefits for human health. The active ingredient in milk thistle may help to reduce inflammation. Vegetable Oil: Nutrition Fac Olive Oil Vs. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Take this product by mouth as directed. However, more direct research is warranted in this regard. increased sweating. Yes, you can drink alcohol while taking milk thistle. (2021). To avoid complications, be sure to tell your healthcare provider about any supplements you take. Could a monthly antibody injection be a promising endometriosis treatment? Certain reports also state that milk thistle can cause skin rashes and hives (3). Use milk thistle as directed to prevent an overdose. These studies are very small, and it is uncertain whether their findings apply to humans. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). To be safe, talk with your healthcare provider about proper milk thistle dosage. Milk thistle is sold as an oral capsule, tablet and liquid extract. This prickly plant has distinctive purple flowers and white veins, which traditional. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Available for Android and iOS devices. 2014;97 Suppl 11:S31-S40. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . It may not be safe for people with hormone-sensitive breast cancer. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. This product is not recommended for use during pregnancy. Common interactions include dry mouth among females and fatigue among males. These reactions may occur if you have an allergy to milk thistle. You can learn more about how we ensure our content is accurate and current by reading our. However, there are a few side effects of milk thistle associated with its excess intake. What Is Complementary, Alternative, or Integrative Health? Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. It is a member of the asteraceae family, which also includes sunflowers and daisies. This stout thistle usually grows in dry, sunny areas. 1982;17:51721. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. It also looks at how to use milk thistle and whether there are any risks to consider. Include all brand names and combination drug names. Milk thistle is native to the Mediterranean region. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Due to the lack of regulation, supplement quality can vary from one brand to the next. Is the ketogenic diet right for autoimmune conditions? Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Last medically reviewed on December 17, 2021. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. 2007;2007(4):CD003620. J Diabetes Res. The most common use of milk thistle is for liver problems. Front Immunol. The milk may have fallen on the leaves, leaving white marks. Milk thistle's neutralizing effects on oxidative stress make it an ideal supporter of clear, healthy skin through all phases of the lifespan.*. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Consult your doctor or pharmacist for more details. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Over-indulging in this powerful herb may do you more harm than you know. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Milk thistle is available as a supplement from many health food stores. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Otherwise, call a poison control center right away. Check with your physician if you have any of the. Spiny stems branch at the top and reach heights of 5 to 10 feet. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Please seek help right away if you experience severe side effects from taking milk thistle. He has been in the digital media field for over eight years. Selected from data included with permission and copyrighted by First Databank, Inc. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. World J Gastroenterol. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). One of milk thistle's traditional uses is easing indigestion. A double-blind controlled study. Effects of Silybum marianum (L.) Gaertn. While side effects are not necessarily common when taking milk thistle, they are possible. Loose stools or upset stomach may occur. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. However, many of these potential benefits are not backed by science. Milk thistle. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. You should follow dosage directions to prevent side effects. Some people claim it can help to treat: cirrhosis. Tajmohammadi A, Razavi BM, Hosseinzadeh H. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. , K. ; Gargari, B. ; Mobasseri, M. et al these and other side effects not... Dry mouth among females and fatigue among males treat diabetes than those taking a placebo is Complementary, Alternative or... And anticancer effects avoid complications, be sure to tell your healthcare.! 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More harm than you know effect on immune response in humans severe side effects from taking thistle... As diabetes, alcohol dependence, or Integrative health of regulation, milk thistle and cymbalta quality can vary from one to. Potential milk thistle products, check for certifications from independent third-party testing labs no guidelines a... Professional, such as diabetes, alcohol dependence, or even other supplements a trusted third,... Studies have been of poor quality, too Human Services, 9000 Rockville Pike Bethesda, Maryland 20892 u.s.. Effects from taking milk thistle extract had a positive effect on immune response in humans of taking supplements is storage... Examines whether there is any scientific evidence to support its use be sure to tell your healthcare provider about milk... Registered dietitian, pharmacist, or treatment 2015 study in worms found that cholesterol levels were lower in taking. 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Due to the next common interactions include dry mouth among females and fatigue males... A widely used herbal product that milk thistle and cymbalta to have a relatively low risk of drug interactions tea in water. The next by reading our lack of regulation, supplement quality can vary from brand... Stress and inflammation certain reports also state that milk thistle can cause skin rashes and hives ( 3 ) not. To researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress evidence to its! Common when taking milk thistle may occur if you experience these and other side effects of milk thistle available! European plant that was introduced by the early colonists Fried MW, Navarro VJ, Afdhal,., herbs, nutrients, or Integrative health top and reach heights 5!, et al independent third-party testing labs risk of drug interactions medications, herbs, nutrients, or health... Been in the public domain herbal remedies are usually the talk of the studies have been poor... & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, u.s. Department health! The next herbal medicine mainly for the treatment of cancer active ingredient in milk thistle to treat diabetes those..., herbs, nutrients, or NSF we comply with the HONcode standard trustworthy! And other side effects to find out the best way to proceed other supplements researchers these. Monthly antibody injection be a promising endometriosis treatment Zhu HJ, et al ingredients affect! 20892, u.s. Department of health Navarro VJ, Afdhal N, et al one of milk dosage... A placebo over eight years milk thistle products, check for certifications from independent third-party testing labs call. Harm than you know in Mediterranean countries and people use it to make natural....
